Human 5'->3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
Article Abstract:
The study aims to demonstrate that CoTC acts as a precursor to termination by presenting a free RNA 5' end that is reorganized by the human 5'->3' exonuclease Xrn2. It is concluded that degradation of the downstream cleavage product by Xrn2 results in transcriptional termination, as envisaged in the torpedo model.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
Article Abstract:
7SK was identified as an abundant and evolutionarily conserved small nuclear RNA as a specific P-TEFb-associated factor, inhibiting general and HIV-1 Tat-specific transcriptional activities of P-TEFb.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
Article Abstract:
Over half of the transcription elongation factor P-TEFb is found to be sequestered, in human HeLa cells, in larger compounds that also contain 7SK RNA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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